The phone has a 6.5-inch touchscreen with a resolution of 1080x2400 pixels and a 20:9 aspect ratio. The Samsung Galaxy A52 has an octa-core Qualcomm Snapdragon 720G processor running at 1.8GHz, with two cores clocked at 2.3GHz and six cores clocke d at 1.8GHz. It has 6GB of RAM. Powered by a 4500mAh battery, the Samsung Galaxy A52 runs Android 11. The Samsung Galaxy A52 supports proprietary fast charging.

As far as the cameras are concerned, the Samsung Galaxy A52 on the rear packs a 64-megapixel primary camera with an f/1.8 aperture; a 12-megapixel camera with an f/2.2 aperture; a 5-megapixel camera with an f/2.4 aperture, and a 5-megapixel camera with an f/2.4 aperture. The rear camera setup has autofocus. It sports a 32-megapixel camera on the front for selfies with an f/2.2 aperture.

The Samsung Galaxy A52 runs One UI 3.1 based on Android 11 and packs 128GB of inbuilt storage that can be expanded via microSD card (up to 1000GB). The Samsung Galaxy A52 is a dual-SIM (GSM and GSM) smartphone that accepts Nano-SIM and Nano-SIM cards. The Samsung Galaxy A52 measures 159.9 x 75.1 x 8.4mm (height x width x thickness) and weighs 189.0grams.

Connectivity options on the Samsung Galaxy A52 include Wi-Fi, GPS, USB Type-C, 3G, and 4G (with support for Band 40 used by some LTE networks in India). Sensors on the phone include an accelerometer, ambient light sensor, compass/ magnetometer, gyroscope, in-display fingerprint sensor, proximity sensor, and fingerprint sensor.